Assay Detail
Binding
CHEMBL3428604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition human HPGDS expressed in Escherichia coli assessed as reduction in GST enzymatic activity using MCBL and glutathione incubated for 30 mins by fluorescence based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hematopoietic prostaglandin D synthase (CHEMBL5879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.00 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261777 | — | — | 1 | 7.64 |
| CHEMBL3425953 | — | — | 1 | 7.58 |
| CHEMBL3425959 | — | — | 1 | 7.51 |
| CHEMBL3425954 | — | — | 1 | 7.50 |
| CHEMBL3425955 | — | — | 1 | 7.46 |
| CHEMBL3425956 | — | — | 1 | 7.37 |
| CHEMBL3425960 | — | — | 1 | 7.32 |
| CHEMBL3425948 | — | — | 1 | 7.22 |
| CHEMBL3425966 | — | — | 1 | 7.16 |
| CHEMBL3425949 | — | — | 1 | 7.16 |
| CHEMBL3425968 | — | — | 1 | 7.15 |
| CHEMBL3425957 | — | — | 1 | 6.89 |
| CHEMBL3425952 | — | — | 1 | 6.77 |
| CHEMBL3425950 | — | — | 1 | 6.75 |
| CHEMBL1233897 | — | — | 1 | 6.70 |
| CHEMBL3425961 | — | — | 1 | 6.64 |
| CHEMBL3425951 | — | — | 1 | 6.52 |
| CHEMBL3425963 | — | — | 1 | 6.50 |
| CHEMBL3425965 | — | — | 1 | 6.23 |
| CHEMBL3425958 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261777 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3425953 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3425959 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3425954 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3425955 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3425956 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3425960 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3425948 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3425966 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3425949 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3425968 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3425957 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3425952 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3425950 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1233897 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3425961 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3425951 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3425963 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3425965 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3425958 | — | IC50 | = | 1200.0 | nM | 5.92 |