Compound Detail
CHEMBL3425966
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Basic Information
| ChEMBL ID | CHEMBL3425966 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXIYNWQDPWQCGB-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
380.4
MW (Da)
2.19
ALogP
4
HBA
2
HBD
78.1
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.16
Kd 1 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hematopoietic prostaglandin D synthase CHEMBL5879 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
| Hematopoietic prostaglandin D synthase CHEMBL5879 | Kd | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hematopoietic prostaglandin D synthase | IC50 | = | 70.0 | nM | 7.16 | Inhibition human HPGDS expressed in Escherichia coli assessed as reduction in GS... | 25978964 |
| Hematopoietic prostaglandin D synthase | Kd | = | 200.0 | nM | 6.7 | Binding affinity to human HPGDS expressed in Escherichia coli using 1-phenylpyra... | 25978964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25978964 | 10.1016/j.bmcl.2015.04.065 | Hematopoietic prostaglandin D synthase | 2 |
Data from ChEMBL 36 via Core Engine