Assay Detail
Binding
CHEMBL3428744
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Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.66 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | 4.0 | 1 | 8.85 |
| CHEMBL26915 | SC-560 | — | 1 | 8.15 |
| CHEMBL3114664 | — | — | 1 | 5.96 |
| CHEMBL3427198 | — | — | 1 | 5.52 |
| CHEMBL3427204 | — | — | 1 | 5.47 |
| CHEMBL3114671 | — | — | 1 | 5.40 |
| CHEMBL3427197 | — | — | 1 | 4.82 |
| CHEMBL3427202 | — | — | 1 | 4.64 |
| CHEMBL3114659 | — | — | 1 | 4.57 |
| CHEMBL3114661 | — | — | 1 | 4.52 |
| CHEMBL363228 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL259972 | MOFEZOLAC | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL26915 | SC-560 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3114664 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3427198 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3427204 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3114671 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3427197 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3427202 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3114659 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3114661 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL363228 | — | IC50 | = | 39000.0 | nM | 4.41 |