Assay Detail
Binding
CHEMBL3429158
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Inhibition of His6-tagged human recombinant Cdc25B catalytic domain (350 to 566 residues) expressed in Escherichia coli BL21 (D3) using OMFP substrate after 30 mins by spectrophotometry
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.63 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426986 | — | — | 1 | 6.19 |
| CHEMBL1715541 | — | — | 1 | 6.11 |
| CHEMBL3426981 | — | — | 1 | 6.11 |
| CHEMBL1522941 | — | — | 1 | 6.08 |
| CHEMBL3426980 | — | — | 1 | 6.07 |
| CHEMBL1453503 | — | — | 1 | 5.94 |
| CHEMBL3426978 | — | — | 1 | 5.92 |
| CHEMBL3426982 | — | — | 1 | 5.81 |
| CHEMBL3426988 | — | — | 1 | 5.75 |
| CHEMBL3426976 | — | — | 1 | 5.73 |
| CHEMBL3426989 | — | — | 1 | 5.70 |
| CHEMBL3426985 | — | — | 1 | 5.64 |
| CHEMBL3426987 | — | — | 1 | 5.61 |
| CHEMBL3426979 | — | — | 1 | 5.59 |
| CHEMBL3426990 | — | — | 1 | 5.50 |
| CHEMBL3426991 | — | — | 1 | 5.50 |
| CHEMBL1611833 | — | — | 1 | 5.48 |
| CHEMBL1712864 | — | — | 1 | 5.47 |
| CHEMBL3426983 | — | — | 1 | 5.42 |
| CHEMBL1719459 | — | — | 1 | 5.38 |
| CHEMBL3426984 | — | — | 1 | 5.35 |
| CHEMBL1707033 | — | — | 1 | 5.28 |
| CHEMBL470594 | — | — | 1 | 5.28 |
| CHEMBL1596475 | — | — | 1 | 4.97 |
| CHEMBL3426977 | — | — | 1 | 4.87 |
| CHEMBL1876186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426986 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1715541 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3426981 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL1522941 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3426980 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1453503 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL3426978 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3426982 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3426988 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3426976 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL3426989 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3426985 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL3426987 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL3426979 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL3426990 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL3426991 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL1611833 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL1712864 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL3426983 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1719459 | — | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL3426984 | — | IC50 | = | 4480.0 | nM | 5.35 |
| CHEMBL1707033 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL470594 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1596475 | — | IC50 | = | 10750.0 | nM | 4.97 |
| CHEMBL3426977 | — | IC50 | = | 13630.0 | nM | 4.87 |
| CHEMBL1876186 | — | IC50 | > | 50000.0 | nM | - |