Assay Detail
ADMET
CHEMBL3532204
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Binding affinity to CYP2A6 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nm
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.59 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | 4.0 | 1 | 5.70 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 5.64 |
| CHEMBL550 | PILOCARPINE | 4.0 | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3989843 | TRANYLCYPROMINE | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL6640 | TRYPTAMINE | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL550 | PILOCARPINE | Kd | = | 3600.0 | nM | 5.44 |