Assay Detail
ADMET
CHEMBL3533736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estrone-3-sulfate substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 1B1 (CHEMBL1697668) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.92 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 5.80 |
| CHEMBL374478 | RIFAMPIN | 4.0 | 1 | 5.64 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.30 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 4.96 |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | 4.68 |
| CHEMBL457 | GEMFIBROZIL | 4.0 | 1 | - |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL374478 | RIFAMPIN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL163 | RITONAVIR | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL472 | GLYBURIDE | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL457 | GEMFIBROZIL | IC50 | = | 130000.0 | nM | - |
| CHEMBL6966 | VERAPAMIL | IC50 | > | 600000.0 | nM | - |