Assay Detail
ADMET
CHEMBL3540468
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Mechanism-based inhibition of recombinant human CYP2C9 expressed in microsomes isolated from Saccharomyces cerevisiae AH22 cells assessed as diclofenac 4'-hydroxylation preincubated for 5 to 10 mins followed by substrate addition measured after 15 mins by HPLC analysis
3
Total Activities
1
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | AH22 |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 5.17 | 5.17 |
| Inhibition | 1 | - | - |
| Kinact | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43469 | ASARININ | — | 3 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43469 | ASARININ | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL43469 | ASARININ | Inhibition | - | % | - | |
| CHEMBL43469 | ASARININ | Kinact | = | 0.17 | /min | - |