Assay Detail
Binding
CHEMBL3579882
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Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.76 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.10 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 6.21 |
| CHEMBL3576979 | — | — | 1 | 5.66 |
| CHEMBL3576986 | — | — | 1 | 5.00 |
| CHEMBL1235806 | — | — | 1 | 4.89 |
| CHEMBL3576976 | — | — | 1 | 4.89 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.82 |
| CHEMBL3576982 | — | — | 1 | 4.70 |
| CHEMBL3576974 | — | — | 1 | 4.36 |
| CHEMBL3576987 | — | — | 1 | 4.18 |
| CHEMBL3576985 | — | — | 1 | 4.15 |
| CHEMBL3576983 | — | — | 1 | 4.12 |
| CHEMBL3576988 | — | — | 1 | 4.06 |
| CHEMBL3576981 | — | — | 1 | 4.04 |
| CHEMBL3113617 | — | — | 1 | 4.04 |
| CHEMBL3576980 | — | — | 1 | 4.01 |
| CHEMBL3576975 | — | — | 1 | - |
| CHEMBL3576978 | — | — | 1 | - |
| CHEMBL3576973 | — | — | 1 | - |
| CHEMBL3576977 | — | — | 1 | - |
| CHEMBL3576984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3576979 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3576986 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL1235806 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3576976 | — | IC50 | = | 12870.0 | nM | 4.89 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3576982 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3576974 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL3576987 | — | IC50 | = | 65520.0 | nM | 4.18 |
| CHEMBL3576985 | — | IC50 | = | 71300.0 | nM | 4.15 |
| CHEMBL3576983 | — | IC50 | = | 76450.0 | nM | 4.12 |
| CHEMBL3576988 | — | IC50 | = | 87220.0 | nM | 4.06 |
| CHEMBL3576981 | — | IC50 | = | 90900.0 | nM | 4.04 |
| CHEMBL3113617 | — | IC50 | = | 90110.0 | nM | 4.04 |
| CHEMBL3576980 | — | IC50 | = | 98310.0 | nM | 4.01 |
| CHEMBL3576975 | — | IC50 | = | 150650.0 | nM | - |
| CHEMBL3576978 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3576973 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3576977 | — | IC50 | = | 104400.0 | nM | - |
| CHEMBL3576984 | — | IC50 | > | 100000.0 | nM | - |