Assay Detail
Functional
CHEMBL3582509
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold hopping of potential anti-tumor agents by WEGA: a shape-based approach
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.69 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 5.36 |
| CHEMBL567 | PERPHENAZINE | 4.0 | 1 | 4.79 |
| CHEMBL3580714 | — | — | 1 | 4.77 |
| CHEMBL723 | CARVEDILOL | 4.0 | 1 | 4.76 |
| CHEMBL1068 | OXCARBAZEPINE | 4.0 | 1 | 4.71 |
| CHEMBL3580715 | — | — | 1 | 4.47 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 4.32 |
| CHEMBL829 | METHYLPROMAZINE | 4.0 | 1 | 4.21 |
| CHEMBL3580711 | — | — | 1 | 4.15 |
| CHEMBL276850 | PHENOXAZINE | — | 1 | - |
| CHEMBL3103368 | — | — | 1 | - |
| CHEMBL63054 | — | — | 1 | - |
| CHEMBL46723 | — | — | 1 | - |
| CHEMBL3580713 | — | — | 1 | - |
| CHEMBL243596 | IMINOSTILBENE | — | 1 | - |
| CHEMBL3580712 | — | — | 1 | - |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | - |
| CHEMBL1316 | CARPROFEN | 4.0 | 1 | - |
| CHEMBL3580710 | — | — | 1 | - |
| CHEMBL1620452 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL567 | PERPHENAZINE | IC50 | = | 16218.1 | nM | 4.79 |
| CHEMBL3580714 | — | IC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL723 | CARVEDILOL | IC50 | = | 17378.01 | nM | 4.76 |
| CHEMBL1068 | OXCARBAZEPINE | IC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL3580715 | — | IC50 | = | 33884.42 | nM | 4.47 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 47863.01 | nM | 4.32 |
| CHEMBL829 | METHYLPROMAZINE | IC50 | = | 61659.5 | nM | 4.21 |
| CHEMBL3580711 | — | IC50 | = | 70794.58 | nM | 4.15 |
| CHEMBL276850 | PHENOXAZINE | IC50 | = | 204173.79 | nM | - |
| CHEMBL1620452 | — | IC50 | > | 158489.32 | nM | - |
| CHEMBL3580710 | — | IC50 | > | 158489.32 | nM | - |
| CHEMBL1316 | CARPROFEN | IC50 | = | 165958.69 | nM | - |
| CHEMBL108 | CARBAMAZEPINE | IC50 | > | 158489.32 | nM | - |
| CHEMBL3580712 | — | IC50 | > | 158489.32 | nM | - |
| CHEMBL243596 | IMINOSTILBENE | IC50 | > | 158489.32 | nM | - |
| CHEMBL3580713 | — | IC50 | > | 158489.32 | nM | - |
| CHEMBL46723 | — | IC50 | = | 123026.88 | nM | - |
| CHEMBL3103368 | — | IC50 | > | 158489.32 | nM | - |
| CHEMBL63054 | — | IC50 | > | 158489.32 | nM | - |