Compound Detail
CHEMBL1068
OXCARBAZEPINE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1068 |
| Name | OXCARBAZEPINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CTRLABGOLIVAIY-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
| Active Moiety | CHEMBL1067 |
2
Targets
2
Activities
1
Assay Types
12
PK Parameters
20
Publications
9
Known Names
12
Indications
1
Mechanisms
Molecular Properties
252.3
MW (Da)
2.64
ALogP
2
HBA
1
HBD
63.4
PSA (Ų)
0.78
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2000 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Sodium channel alpha subunit blocker | BLOCKER | Sodium channel alpha subunit | ✓ | ✓ |
Indications
Epilepsy Seizures Aggression Anxiety Dementia Depressive Disorder Epilepsies, Partial Neuralgia Psychomotor Agitation Schizophrenia Multiple Sclerosis Neoplasms
ATC Classification
N03AF02
oxcarbazepine
Level 1: NERVOUS SYSTEM
Level 2: ANTIEPILEPTICS
Activity Summary
IC50 2 meas. best 4.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HepG2 CHEMBL395 | IC50 | 4.71 | 4.71 | 19498.5 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.55 | 4.55 | 28100.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 77699.16 | ng.hr.mL-1 | Homo sapiens |
| AUC | 1715.44 | ng.hr.mL-1 | Homo sapiens |
| AUC | 118.57 | ng.hr.mL-1 | Homo sapiens |
| Cmax | 2000.0 | nM | Homo sapiens |
| Cmax | 80.0 | nM | Homo sapiens |
| Excretion | 27.0 | % | Homo sapiens |
| F | 0.99 | % | Homo sapiens |
| T1/2 | 2.0 | hr | Homo sapiens |
| Tmax | 0.08333 | hr | Rattus norvegicus |
| Tmax | 2.0 | hr | Rattus norvegicus |
| Tmax | 1.0 | hr | Homo sapiens |
| Tmax | 0.5 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HepG2 | IC50 | = | 19498.45 | nM | 4.71 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability a... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 28100.0 | nM | 4.55 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
Literature References
Data from ChEMBL 36 via Core Engine