Assay Detail
Functional
CHEMBL3583527
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MOLM13 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.94 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957266 | — | — | 1 | 7.25 |
| CHEMBL3581661 | — | — | 1 | 7.18 |
| CHEMBL3581660 | — | — | 1 | 7.11 |
| CHEMBL3581662 | — | — | 1 | 6.84 |
| CHEMBL2017291 | — | — | 1 | 6.64 |
| CHEMBL1232461 | MOLIBRESIB | 2.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957266 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3581661 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3581660 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL3581662 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL2017291 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1232461 | MOLIBRESIB | IC50 | = | 241.0 | nM | 6.62 |