Assay Detail
Functional
CHEMBL3583791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inhibition of nitric oxide production preincubated for 30 mins followed by LPS stimulation measured after 24 hrs by Griess assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lignan Glycosides from the Twigs of Chaenomeles sinensis and Their Biological Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.52 | 4.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581700 | — | — | 1 | 4.67 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.61 |
| CHEMBL3581699 | — | — | 1 | 4.53 |
| CHEMBL3581702 | — | — | 1 | 4.50 |
| CHEMBL464198 | — | — | 1 | 4.42 |
| CHEMBL2332673 | AVICULIN | — | 1 | 4.40 |
| CHEMBL3581698 | — | — | 1 | - |
| CHEMBL3581697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581700 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL256147 | TILARGININE | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL3581699 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL3581702 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL464198 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL2332673 | AVICULIN | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL3581698 | — | IC50 | = | 199300.0 | nM | - |
| CHEMBL3581697 | — | IC50 | = | 179700.0 | nM | - |