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Compound Detail

CHEMBL2332673

AVICULIN
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COc1cc([C@H]2c3cc(O)c(OC)cc3C[C@@H](CO)[C@@H]2CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)ccc1O

Basic Information

ChEMBL ID CHEMBL2332673
Name AVICULIN
Phase Preclinical
Structure Type MOL
InChI Key FPJFPMQEUVMUKU-CDDCGRQRSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

506.6
MW (Da)
0.87
ALogP
10
HBA
6
HBD
158.3
PSA (Ų)
0.32
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H34O10
MW 506.55
Aromatic Rings 2
Heavy Atoms 36
NP-Likeness 2.12

Activity Summary

IC50 1 meas. best 4.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.4 4.4 40200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET IC50 = 40200.0 nM 4.4 Antiinflammatory activity against LPS-stimulated mouse BV2 cells assessed as inh... 25894905

Literature References

Data from ChEMBL 36 via Core Engine