Assay Detail
Binding
CHEMBL3584104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H][Ile5,6]deltorphin-2 from delta opioid receptor in Wistar rat brain membranes after 120 mins by scintillation counting analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed opioid affinity cyclic endomorphin-2 analogues with fluorinated phenylalanines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.76 | 7.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3580749 | — | — | 1 | 7.95 |
| CHEMBL3580743 | — | — | 1 | 6.96 |
| CHEMBL3580748 | — | — | 1 | 6.78 |
| CHEMBL3580745 | — | — | 1 | 6.55 |
| CHEMBL3582487 | — | — | 1 | 6.54 |
| CHEMBL3580746 | — | — | 1 | 6.47 |
| CHEMBL3582484 | — | — | 1 | 6.46 |
| CHEMBL3580744 | — | — | 1 | 6.37 |
| CHEMBL3580750 | — | — | 1 | - |
| CHEMBL3580747 | — | — | 1 | - |
| CHEMBL3582486 | — | — | 1 | - |
| CHEMBL3582485 | — | — | 1 | - |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3580749 | — | IC50 | = | 11.2 | nM | 7.95 |
| CHEMBL3580743 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3580748 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3580745 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3582487 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL3580746 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL3582484 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL3580744 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL3580750 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3580747 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3582486 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3582485 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | > | 1000.0 | nM | - |