Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3584884

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human Jurkat cells incubated for 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B, Rosenthal PJ, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y.
J Med Chem (2015) 58 : 5344 -5354
PubMed 26067904 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.56 5.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3581479 1 5.12
CHEMBL3581497 1 4.78
CHEMBL3581499 1 4.75
CHEMBL3581485 1 4.32
CHEMBL3581503 1 4.28
CHEMBL3581487 1 4.10
CHEMBL3581501 1 -
CHEMBL3581500 1 -
CHEMBL3581498 1 -
CHEMBL3581488 1 -
CHEMBL1761275 1 -
CHEMBL3581476 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3581479 IC50 = 7590.0 nM 5.12
CHEMBL3581497 IC50 = 16800.0 nM 4.78
CHEMBL3581499 IC50 = 17600.0 nM 4.75
CHEMBL3581485 IC50 = 48200.0 nM 4.32
CHEMBL3581503 IC50 = 52400.0 nM 4.28
CHEMBL3581487 IC50 = 79900.0 nM 4.10
CHEMBL3581501 IC50 > 100000.0 nM -
CHEMBL3581500 IC50 > 100000.0 nM -
CHEMBL3581498 IC50 > 100000.0 nM -
CHEMBL3581488 IC50 > 100000.0 nM -
CHEMBL1761275 IC50 > 100000.0 nM -
CHEMBL3581476 IC50 > 100000.0 nM -