Assay Detail
ADMET
CHEMBL3585200
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Inhibition of CYP3A4 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.38 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3581132 | — | — | 1 | 6.32 |
| CHEMBL3581121 | — | — | 1 | 6.12 |
| CHEMBL3581144 | — | — | 1 | 5.82 |
| CHEMBL3581138 | — | — | 1 | 5.70 |
| CHEMBL3581142 | — | — | 1 | 5.46 |
| CHEMBL3581145 | — | — | 1 | 5.44 |
| CHEMBL3581146 | — | — | 1 | 5.42 |
| CHEMBL3581147 | — | — | 1 | 5.30 |
| CHEMBL3581149 | — | — | 1 | 5.25 |
| CHEMBL3581139 | — | — | 1 | 5.13 |
| CHEMBL3581148 | — | — | 1 | 5.12 |
| CHEMBL3581143 | — | — | 1 | 5.08 |
| CHEMBL3581137 | — | — | 1 | 5.00 |
| CHEMBL3581141 | — | — | 1 | 4.94 |
| CHEMBL3581140 | — | — | 1 | 4.58 |
| CHEMBL3580669 | — | — | 1 | - |
| CHEMBL3581150 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3581132 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3581121 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3581144 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3581138 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3581142 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3581145 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3581146 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3581147 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3581149 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3581139 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3581148 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3581143 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3581137 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3581141 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3581140 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3580669 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3581150 | — | IC50 | > | 15000.0 | nM | - |