Assay Detail
Binding
CHEMBL3586822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Sprague-Dawley rat brain microsomal FAAH using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate assessed as 4-pyren-1-ylbutanoic acid release preincubated for 10 mins with substrate followed by protein addition measured after 60 mins by reverse phase HPLC with fluorescence detection method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Microsomal |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.50 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175854 | — | — | 1 | 8.54 |
| CHEMBL3585527 | — | — | 1 | 8.44 |
| CHEMBL3585528 | — | — | 1 | 8.28 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.22 |
| CHEMBL3585525 | — | — | 1 | 7.05 |
| CHEMBL3585524 | — | — | 1 | 7.03 |
| CHEMBL3585526 | — | — | 1 | 6.62 |
| CHEMBL3585519 | — | — | 1 | 6.60 |
| CHEMBL3585522 | — | — | 1 | 6.54 |
| CHEMBL3585515 | — | — | 1 | 6.51 |
| CHEMBL233593 | — | — | 1 | 6.46 |
| CHEMBL3585514 | — | — | 1 | 6.34 |
| CHEMBL3585518 | — | — | 1 | 6.28 |
| CHEMBL3585521 | — | — | 1 | 6.09 |
| CHEMBL3585520 | — | — | 1 | 6.04 |
| CHEMBL3585523 | — | — | 1 | 6.02 |
| CHEMBL3585508 | — | — | 1 | 5.58 |
| CHEMBL3585516 | — | — | 1 | 5.33 |
| CHEMBL3585517 | — | — | 1 | 5.31 |
| CHEMBL3585509 | — | — | 1 | 5.21 |
| CHEMBL3585513 | — | — | 1 | 5.06 |
| CHEMBL3585511 | — | — | 1 | - |
| CHEMBL3585512 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175854 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3585527 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3585528 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL184238 | URB-597 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3585525 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3585524 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3585526 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3585519 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3585522 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3585515 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL233593 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3585514 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3585518 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3585521 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3585520 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3585523 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3585508 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3585516 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3585517 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3585509 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3585513 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3585511 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3585512 | — | IC50 | > | 10000.0 | nM | - |