Compound Detail
CHEMBL233593
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL233593 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KCHOVCICRIAYSX-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
453.6
MW (Da)
6.87
ALogP
4
HBA
1
HBD
56.1
PSA (Ų)
0.27
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 8.28 | 8.28 | 5.3 | 1 |
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 6.47 | 6.465 | 340.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 5.3 | nM | 8.28 | Inhibition of human FAAH expressed in H4 cells | 17459705 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 340.0 | nM | 6.47 | Inhibition of Sprague-Dawley rat brain microsome FAAH assessed as reduction in 4... | 22196515 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 350.0 | nM | 6.46 | Inhibition of Sprague-Dawley rat brain microsomal FAAH using N-(2-hydroxyethyl)-... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17459705 | 10.1016/j.bmcl.2007.04.009 | Fatty-acid amide hydrolase 1 | 1 |
| 22196515 | 10.1016/j.bmc.2011.11.027 | Fatty-acid amide hydrolase 1 | 1 |
| - | 10.1039/C4MD00181H | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine