Assay Detail
Binding
CHEMBL894550
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Inhibition of human FAAH expressed in H4 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel inhibitors of fatty acid amide hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL232782 | — | — | 1 | 8.70 |
| CHEMBL232783 | — | — | 1 | 8.38 |
| CHEMBL233593 | — | — | 1 | 8.28 |
| CHEMBL393156 | — | — | 1 | 8.00 |
| CHEMBL237044 | — | — | 1 | 7.96 |
| CHEMBL232786 | — | — | 1 | 7.62 |
| CHEMBL232784 | — | — | 1 | 7.52 |
| CHEMBL234003 | — | — | 1 | 7.51 |
| CHEMBL237043 | — | — | 1 | 7.50 |
| CHEMBL232785 | — | — | 1 | 7.19 |
| CHEMBL234879 | — | — | 1 | 7.19 |
| CHEMBL428727 | — | — | 1 | 7.04 |
| CHEMBL393155 | — | — | 1 | 6.96 |
| CHEMBL392067 | — | — | 1 | 6.89 |
| CHEMBL233594 | — | — | 1 | 6.60 |
| CHEMBL401425 | — | — | 1 | 6.17 |
| CHEMBL445160 | — | — | 1 | 6.01 |
| CHEMBL232992 | — | — | 1 | 5.77 |
| CHEMBL428372 | — | — | 1 | 5.19 |
| CHEMBL391682 | — | — | 1 | 5.00 |
| CHEMBL232991 | — | — | 1 | 5.00 |
| CHEMBL232787 | — | — | 1 | - |
| CHEMBL233792 | — | — | 1 | - |
| CHEMBL392706 | — | — | 1 | - |
| CHEMBL233596 | — | — | 1 | - |
| CHEMBL233595 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL232782 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL232783 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL233593 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL393156 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL237044 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL232786 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL232784 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL234003 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL237043 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL232785 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL234879 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL428727 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL393155 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL392067 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL233594 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL401425 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL445160 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL232992 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL428372 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL391682 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL232991 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL232787 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL233792 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL392706 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL233596 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL233595 | — | IC50 | > | 100000.0 | nM | - |