Compound Detail
CHEMBL237044
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Basic Information
| ChEMBL ID | CHEMBL237044 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BAMAEDLXPIBVOC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
404.6
MW (Da)
6.29
ALogP
4
HBA
0
HBD
44.1
PSA (Ų)
0.28
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL2243 | IC50 | 7.96 | 7.96 | 11.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of human FAAH expressed in H4 cells | 17459705 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 11.0 | nM | 7.96 | Inhibition of FAAH | 18983142 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17459705 | 10.1016/j.bmcl.2007.04.009 | Fatty-acid amide hydrolase 1 | 1 |
| 18983142 | 10.1021/jm800311k | Fatty-acid amide hydrolase 1 | 1 |
Data from ChEMBL 36 via Core Engine