Assay Detail
Binding
CHEMBL938648
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Inhibition of FAAH
123
Total Activities
123
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 98 | 7.28 | 9.70 |
| IC50 | 25 | 6.18 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272111 | — | — | 1 | 9.70 |
| CHEMBL175854 | — | — | 1 | 9.70 |
| CHEMBL367966 | — | — | 1 | 9.55 |
| CHEMBL464186 | — | — | 1 | 9.52 |
| CHEMBL179760 | — | — | 1 | 9.41 |
| CHEMBL182199 | — | — | 1 | 9.28 |
| CHEMBL483697 | — | — | 1 | 9.20 |
| CHEMBL227046 | — | — | 1 | 9.12 |
| CHEMBL388599 | — | — | 1 | 9.05 |
| CHEMBL226938 | — | — | 1 | 9.00 |
| CHEMBL467368 | — | — | 1 | 8.96 |
| CHEMBL232782 | — | — | 1 | 8.70 |
| CHEMBL374895 | — | — | 1 | 8.70 |
| CHEMBL457924 | — | — | 1 | 8.64 |
| CHEMBL428874 | — | — | 1 | 8.44 |
| CHEMBL512377 | — | — | 1 | 8.43 |
| CHEMBL441556 | — | — | 1 | 8.30 |
| CHEMBL223406 | — | — | 1 | 8.22 |
| CHEMBL257638 | — | — | 1 | 8.16 |
| CHEMBL457925 | — | — | 1 | 8.14 |
| CHEMBL457814 | — | — | 1 | 8.05 |
| CHEMBL220571 | — | — | 1 | 8.00 |
| CHEMBL385097 | — | — | 1 | 8.00 |
| CHEMBL459004 | — | — | 1 | 7.96 |
| CHEMBL237044 | — | — | 1 | 7.96 |
| CHEMBL422064 | — | — | 1 | 7.92 |
| CHEMBL223302 | — | — | 1 | 7.92 |
| CHEMBL457918 | — | — | 1 | 7.89 |
| CHEMBL219932 | — | — | 1 | 7.82 |
| CHEMBL506602 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175854 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL272111 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL367966 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL464186 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL179760 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL182199 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL483697 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL227046 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL388599 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL226938 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL467368 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL232782 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL374895 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL457924 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL428874 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL512377 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL441556 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL223406 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL257638 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL457925 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL457814 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL385097 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL220571 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL237044 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL459004 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL422064 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL223302 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL457918 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL219932 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL506602 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL457506 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL515538 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL375303 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL229484 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL219674 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL456447 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL220005 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL220518 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL220376 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL220125 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL222463 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL373814 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL387376 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL457518 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL229483 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL515533 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL222613 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL223435 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL458941 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL222614 | — | Ki | = | 62.0 | nM | 7.21 |