Assay Detail
Binding
CHEMBL3587151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human SERT S438T mutant expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.19 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3586681 | — | — | 1 | 5.42 |
| CHEMBL3586683 | — | — | 1 | 5.24 |
| CHEMBL1508 | ESCITALOPRAM | 4.0 | 1 | 5.10 |
| CHEMBL3586682 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3586681 | — | Ki | = | 3811.0 | nM | 5.42 |
| CHEMBL3586683 | — | Ki | = | 5697.0 | nM | 5.24 |
| CHEMBL1508 | ESCITALOPRAM | Ki | = | 7879.0 | nM | 5.10 |
| CHEMBL3586682 | — | Ki | = | 9879.0 | nM | 5.00 |