Assay Detail
Binding
CHEMBL3590859
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of (-)-[3H]pentazocine from sigma1 receptor in Sprague-Dawley rat cortical membranes incubated for 2 hrs by liquid scintillation counting based competitive radioligand binding assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 54 | 7.16 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264437 | — | — | 1 | 8.24 |
| CHEMBL3589731 | — | — | 1 | 8.05 |
| CHEMBL3589719 | — | — | 1 | 8.04 |
| CHEMBL3590030 | — | — | 1 | 8.01 |
| CHEMBL3589872 | — | — | 1 | 7.98 |
| CHEMBL3589714 | — | — | 1 | 7.80 |
| CHEMBL3589712 | — | — | 1 | 7.78 |
| CHEMBL3589869 | — | — | 1 | 7.78 |
| CHEMBL3589715 | — | — | 1 | 7.71 |
| CHEMBL3589865 | — | — | 1 | 7.70 |
| CHEMBL20730 | VESAMICOL | — | 1 | 7.69 |
| CHEMBL3589863 | — | — | 1 | 7.65 |
| CHEMBL3589720 | — | — | 1 | 7.64 |
| CHEMBL3589727 | — | — | 1 | 7.62 |
| CHEMBL3589876 | — | — | 1 | 7.60 |
| CHEMBL3589724 | — | — | 1 | 7.59 |
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 7.58 |
| CHEMBL3589711 | — | — | 1 | 7.58 |
| CHEMBL3589871 | — | — | 1 | 7.52 |
| CHEMBL3589716 | — | — | 1 | 7.51 |
| CHEMBL3589723 | — | — | 1 | 7.39 |
| CHEMBL3589864 | — | — | 1 | 7.37 |
| CHEMBL3589873 | — | — | 1 | 7.33 |
| CHEMBL3589866 | — | — | 1 | 7.26 |
| CHEMBL3589732 | — | — | 1 | 7.26 |
| CHEMBL3589879 | — | — | 1 | 7.23 |
| CHEMBL3589877 | — | — | 1 | 7.23 |
| CHEMBL1089853 | — | — | 1 | 7.21 |
| CHEMBL3589874 | — | — | 1 | 7.20 |
| CHEMBL3589729 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264437 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL3589731 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL3589719 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL3590030 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL3589872 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL3589714 | — | Ki | = | 15.9 | nM | 7.80 |
| CHEMBL3589712 | — | Ki | = | 16.8 | nM | 7.78 |
| CHEMBL3589869 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL3589715 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL3589865 | — | Ki | = | 20.1 | nM | 7.70 |
| CHEMBL20730 | VESAMICOL | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL3589863 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL3589720 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL3589727 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL3589876 | — | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL3589724 | — | Ki | = | 25.9 | nM | 7.59 |
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 26.1 | nM | 7.58 |
| CHEMBL3589711 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL3589871 | — | Ki | = | 29.9 | nM | 7.52 |
| CHEMBL3589716 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3589723 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL3589864 | — | Ki | = | 43.2 | nM | 7.37 |
| CHEMBL3589873 | — | Ki | = | 47.3 | nM | 7.33 |
| CHEMBL3589866 | — | Ki | = | 54.3 | nM | 7.26 |
| CHEMBL3589732 | — | Ki | = | 55.3 | nM | 7.26 |
| CHEMBL3589879 | — | Ki | = | 59.4 | nM | 7.23 |
| CHEMBL3589877 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL1089853 | — | Ki | = | 60.9 | nM | 7.21 |
| CHEMBL3589874 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL3589729 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL3589722 | — | Ki | = | 65.4 | nM | 7.18 |
| CHEMBL3589728 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL3590029 | — | Ki | = | 83.9 | nM | 7.08 |
| CHEMBL3589725 | — | Ki | = | 97.6 | nM | 7.01 |
| CHEMBL3589870 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL3590031 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL3589717 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL87381 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL3589713 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL1271793 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL473129 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL3589730 | — | Ki | = | 248.0 | nM | 6.61 |
| CHEMBL3589736 | — | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL3589721 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3589875 | — | Ki | = | 456.0 | nM | 6.34 |
| CHEMBL3589862 | — | Ki | = | 454.0 | nM | 6.34 |
| CHEMBL3589726 | — | Ki | = | 466.0 | nM | 6.33 |
| CHEMBL3589878 | — | Ki | = | 553.0 | nM | 6.26 |
| CHEMBL3589735 | — | Ki | = | 626.0 | nM | 6.20 |
| CHEMBL3589718 | — | Ki | = | 736.0 | nM | 6.13 |