Assay Detail
Functional
CHEMBL3591242
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Inhibition of cell proliferation of human Jurkat cells incubated for 72 hrs by Celltiter-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.21 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3589752 | IPP/CNRS-A017 | — | 1 | 7.70 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.70 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3589752 | IPP/CNRS-A017 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 60000.0 | nM | 4.22 |