Assay Detail
Functional
CHEMBL3592364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms by microtiter plate based assay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.92 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | 3.0 | 1 | 7.52 |
| CHEMBL3589914 | — | — | 1 | 6.35 |
| CHEMBL3589916 | — | — | 1 | 6.32 |
| CHEMBL3589930 | — | — | 1 | 6.29 |
| CHEMBL3589924 | — | — | 1 | 6.28 |
| CHEMBL3589980 | — | — | 1 | 6.28 |
| CHEMBL3589983 | — | — | 1 | 6.28 |
| CHEMBL3589932 | — | — | 1 | 6.26 |
| CHEMBL3589922 | — | — | 1 | 6.25 |
| CHEMBL3589981 | — | — | 1 | 6.24 |
| CHEMBL3589935 | — | — | 1 | 6.22 |
| CHEMBL3589984 | — | — | 1 | 6.21 |
| CHEMBL3589927 | — | — | 1 | 6.21 |
| CHEMBL3589917 | — | — | 1 | 6.19 |
| CHEMBL3589929 | — | — | 1 | 6.19 |
| CHEMBL3589919 | — | — | 1 | 6.19 |
| CHEMBL3589985 | — | — | 1 | 6.18 |
| CHEMBL3589923 | — | — | 1 | 6.16 |
| CHEMBL3589933 | — | — | 1 | 6.14 |
| CHEMBL3589918 | — | — | 1 | 6.12 |
| CHEMBL3589926 | — | — | 1 | 6.11 |
| CHEMBL3589925 | — | — | 1 | 6.05 |
| CHEMBL3589936 | — | — | 1 | 5.96 |
| CHEMBL3589979 | — | — | 1 | 5.93 |
| CHEMBL3589928 | — | — | 1 | 5.92 |
| CHEMBL3589008 | — | — | 1 | 5.83 |
| CHEMBL3589982 | — | — | 1 | 5.83 |
| CHEMBL3589921 | — | — | 1 | 5.83 |
| CHEMBL3589915 | — | — | 1 | 5.83 |
| CHEMBL3589931 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265502 | SURAMIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3589914 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3589916 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3589930 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3589924 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3589980 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3589983 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3589932 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3589922 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3589981 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3589935 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3589984 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3589927 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3589919 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3589917 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3589929 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3589985 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL3589923 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3589933 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3589918 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3589926 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3589925 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3589936 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3589979 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL3589928 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3589008 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3589915 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3589982 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3589921 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL3589931 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL3589920 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL3589986 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3589934 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL3589005 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3589003 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3589004 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL170 | QUININE | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 25990.0 | nM | 4.58 |
| CHEMBL533841 | CINCHONIDINE | IC50 | = | 62180.0 | nM | 4.21 |
| CHEMBL1478 | LITHOCHOLIC ACID | IC50 | - | — | - | |
| CHEMBL205596 | CHOLIC ACID | IC50 | - | — | - | |
| CHEMBL240597 | CHENODIOL | IC50 | - | — | - | |
| CHEMBL272621 | HYODEOXYCHOLIC_ACID | IC50 | - | — | - | |
| CHEMBL1908063 | HYOCHOLIC ACID | IC50 | - | — | - | |
| CHEMBL406393 | DEOXYCHOLIC ACID | IC50 | - | — | - | |
| CHEMBL3589007 | — | IC50 | - | — | - | |
| CHEMBL3589006 | — | IC50 | - | — | - | |
| CHEMBL272041 | — | IC50 | - | — | - | |
| CHEMBL269671 | ARTEMISININ | IC50 | - | — | - | |
| CHEMBL65 | CAMPTOTHECIN | IC50 | - | — | - |