Assay Detail
Binding
CHEMBL3594629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig liver microsomes HMG-CoA reductase incubated for 5 mins in using HMG-CoA and NADPH by colorimetric method
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3593154) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.66 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1915760 | GANODERIC ACID Y | — | 1 | 5.07 |
| CHEMBL1099224 | GANODERIC ACID DM | — | 2 | 5.02 |
| CHEMBL3594152 | — | — | 1 | 4.97 |
| CHEMBL1097154 | GANODERIC ACID S | — | 1 | 4.90 |
| CHEMBL3594158 | — | — | 1 | 4.90 |
| CHEMBL3594153 | — | — | 1 | 4.88 |
| CHEMBL1915763 | GANODERMANONTRIOL | — | 1 | 4.78 |
| CHEMBL3594142 | — | — | 1 | 4.77 |
| CHEMBL3594154 | — | — | 1 | 4.72 |
| CHEMBL3594147 | — | — | 1 | 4.69 |
| CHEMBL3594155 | — | — | 1 | 4.62 |
| CHEMBL3594144 | — | — | 1 | 4.58 |
| CHEMBL3594151 | — | — | 1 | 4.58 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 1 | 4.49 |
| CHEMBL3594149 | — | — | 1 | 4.48 |
| CHEMBL3594143 | — | — | 1 | 4.17 |
| CHEMBL3594145 | — | — | 1 | 4.01 |
| CHEMBL3594156 | — | — | 1 | - |
| CHEMBL3594157 | — | — | 1 | - |
| CHEMBL3594150 | — | — | 1 | - |
| CHEMBL457601 | GANODERONE A | — | 1 | - |
| CHEMBL3594159 | — | — | 1 | - |
| CHEMBL1915761 | GANODERIOL F | — | 1 | - |
| CHEMBL3594148 | — | — | 1 | - |
| CHEMBL3594160 | — | — | 1 | - |
| CHEMBL3594146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1915760 | GANODERIC ACID Y | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1099224 | GANODERIC ACID DM | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3594152 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1097154 | GANODERIC ACID S | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3594158 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3594153 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL1915763 | GANODERMANONTRIOL | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL3594142 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL3594154 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3594147 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL3594155 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL3594144 | — | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL3594151 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL3594149 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL1099224 | GANODERIC ACID DM | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL3594143 | — | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL3594145 | — | IC50 | = | 97500.0 | nM | 4.01 |
| CHEMBL3594156 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594157 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL457601 | GANODERONE A | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594159 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1915761 | GANODERIOL F | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594148 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594160 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3594146 | — | IC50 | > | 100000.0 | nM | - |