Assay Detail
Binding
CHEMBL3595953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ifenprodil from rat cortical membranes NMDA receptor by beta counting analysis in absence of spermine
79
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 79 | 4.93 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594017 | — | — | 1 | 6.39 |
| CHEMBL1169964 | — | — | 1 | 6.12 |
| CHEMBL3594018 | — | — | 1 | 6.08 |
| CHEMBL181480 | — | — | 1 | 5.85 |
| CHEMBL3594016 | — | — | 1 | 5.83 |
| CHEMBL249456 | — | — | 1 | 5.40 |
| CHEMBL3594012 | — | — | 1 | 5.34 |
| CHEMBL1170548 | — | — | 1 | 5.15 |
| CHEMBL185172 | — | — | 1 | 5.14 |
| CHEMBL3594080 | — | — | 1 | 5.04 |
| CHEMBL365916 | — | — | 1 | 4.97 |
| CHEMBL3594013 | — | — | 1 | 4.94 |
| CHEMBL1170755 | — | — | 1 | 4.89 |
| CHEMBL3594011 | — | — | 1 | 4.78 |
| CHEMBL9126 | — | — | 1 | 4.77 |
| CHEMBL1170985 | — | — | 1 | 4.77 |
| CHEMBL3594008 | — | — | 1 | 4.72 |
| CHEMBL269032 | — | — | 1 | 4.72 |
| CHEMBL3594010 | — | — | 1 | 4.69 |
| CHEMBL3594014 | — | — | 1 | 4.66 |
| CHEMBL102740 | ARCAINE | — | 1 | 4.61 |
| CHEMBL183814 | BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE | — | 1 | 4.57 |
| CHEMBL3594081 | — | — | 1 | 4.51 |
| CHEMBL3593840 | — | — | 1 | 4.49 |
| CHEMBL3594007 | — | — | 1 | 4.36 |
| CHEMBL1852874 | — | — | 1 | 4.31 |
| CHEMBL229102 | — | — | 1 | 4.31 |
| CHEMBL185063 | — | — | 1 | 4.26 |
| CHEMBL3593841 | — | — | 1 | 4.20 |
| CHEMBL22629 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594017 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1169964 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3594018 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL181480 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL3594016 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL249456 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL3594012 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL1170548 | — | IC50 | = | 7140.0 | nM | 5.15 |
| CHEMBL185172 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL3594080 | — | IC50 | = | 9160.0 | nM | 5.04 |
| CHEMBL365916 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3594013 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1170755 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3594011 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL1170985 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL9126 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3594008 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL269032 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL3594010 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL3594014 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL102740 | ARCAINE | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL183814 | BIS(4-CARBAMIMIDOYLPHENYL)TEREPHTHALATE | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3594081 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL3593840 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL3594007 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL1852874 | — | IC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL229102 | — | IC50 | = | 49300.0 | nM | 4.31 |
| CHEMBL185063 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL3593841 | — | IC50 | = | 63800.0 | nM | 4.20 |
| CHEMBL22629 | — | IC50 | = | 77700.0 | nM | 4.11 |
| CHEMBL1851600 | — | IC50 | - | — | - | |
| CHEMBL1851728 | — | IC50 | - | — | - | |
| CHEMBL142952 | — | IC50 | - | — | - | |
| CHEMBL9391 | — | IC50 | - | — | - | |
| CHEMBL1852582 | — | IC50 | - | — | - | |
| CHEMBL24057 | FURAMIDINE | IC50 | - | — | - | |
| CHEMBL284933 | — | IC50 | - | — | - | |
| CHEMBL279660 | — | IC50 | - | — | - | |
| CHEMBL3594195 | — | IC50 | - | — | - | |
| CHEMBL165542 | — | IC50 | - | — | - | |
| CHEMBL3594197 | — | IC50 | - | — | - | |
| CHEMBL1232046 | — | IC50 | - | — | - | |
| CHEMBL3594196 | — | IC50 | - | — | - | |
| CHEMBL1962539 | — | IC50 | - | — | - | |
| CHEMBL1963649 | — | IC50 | - | — | - | |
| CHEMBL1963648 | — | IC50 | - | — | - | |
| CHEMBL1963636 | — | IC50 | - | — | - | |
| CHEMBL1080776 | — | IC50 | - | — | - | |
| CHEMBL1081887 | — | IC50 | - | — | - | |
| CHEMBL424711 | — | IC50 | - | — | - |