Assay Detail
Functional
CHEMBL3602174
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Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by resazurin assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.21 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601867 | — | — | 1 | 8.70 |
| CHEMBL3601866 | — | — | 1 | 8.70 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.52 |
| CHEMBL2393394 | — | — | 1 | 7.70 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 7.16 |
| CHEMBL3601865 | — | — | 1 | 7.05 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 7.05 |
| CHEMBL3601864 | — | — | 1 | 5.56 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 4.43 |
| CHEMBL3601863 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601867 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3601866 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2393394 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3601865 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3601864 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL3601863 | — | IC50 | = | 173900.0 | nM | - |