Assay Detail
Functional
CHEMBL3602364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against T-cell line-tropic HIV1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathogenicity after 5 days by MTT assay in presence of 5 uM of chloroquine
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-HIV screening for cell-penetrating peptides using chloroquine and identification of anti-HIV peptides derived from matrix proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.07 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.89 |
| CHEMBL18442 | PLERIXAFOR | 4.0 | 1 | 7.60 |
| CHEMBL3600990 | — | — | 1 | 6.21 |
| CHEMBL3600987 | — | — | 1 | 6.19 |
| CHEMBL3600985 | — | — | 1 | 6.07 |
| CHEMBL3600986 | — | — | 1 | 6.00 |
| CHEMBL3600988 | — | — | 1 | 5.77 |
| CHEMBL3600989 | — | — | 1 | 5.70 |
| CHEMBL3600983 | — | — | 1 | 5.35 |
| CHEMBL3600984 | — | — | 1 | 5.34 |
| CHEMBL1946511 | — | — | 1 | 4.66 |
| CHEMBL3600898 | — | — | 1 | - |
| CHEMBL3600899 | — | — | 1 | - |
| CHEMBL3600991 | — | — | 1 | - |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL18442 | PLERIXAFOR | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3600990 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL3600987 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3600985 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3600986 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3600988 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3600989 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3600983 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3600984 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1946511 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3600898 | — | EC50 | > | 8700.0 | nM | - |
| CHEMBL3600899 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3600991 | — | EC50 | > | 8200.0 | nM | - |
| CHEMBL82301 | VICRIVIROC | EC50 | > | 5000.0 | nM | - |