Assay Detail
Functional
CHEMBL3602579
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated nitric oxide production after 24 hrs by Griess method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.73 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3600407 | — | — | 1 | 5.14 |
| CHEMBL3600408 | — | — | 1 | 5.00 |
| CHEMBL3600411 | — | — | 1 | 4.97 |
| CHEMBL243148 | SOPHORAFLAVANONE G | — | 1 | 4.96 |
| CHEMBL453642 | LEACHIANONE A | — | 1 | 4.95 |
| CHEMBL3600413 | — | — | 1 | 4.94 |
| CHEMBL3600410 | — | — | 1 | 4.90 |
| CHEMBL3600409 | — | — | 1 | 4.84 |
| CHEMBL3600405 | — | — | 1 | 4.80 |
| CHEMBL425926 | CUDRAXANTHONE D | — | 1 | 4.79 |
| CHEMBL3600406 | — | — | 1 | 4.72 |
| CHEMBL519277 | KUSHENOL P | — | 1 | 4.69 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 4.69 |
| CHEMBL3600415 | — | — | 1 | 4.64 |
| CHEMBL3600412 | — | — | 1 | 4.64 |
| CHEMBL460647 | SOPHORAFLAVANONE B | — | 1 | 4.58 |
| CHEMBL243796 | KURARINONE | — | 1 | 4.58 |
| CHEMBL3600403 | — | — | 1 | 4.56 |
| CHEMBL556429 | — | — | 1 | 4.54 |
| CHEMBL3600402 | — | — | 1 | 4.49 |
| CHEMBL491534 | ISOBAVACHIN | — | 1 | 4.33 |
| CHEMBL3600414 | — | — | 1 | 4.32 |
| CHEMBL480462 | PALLIDOL | — | 1 | - |
| CHEMBL454878 | TRIFOLIRHIZIN | — | 1 | - |
| CHEMBL3600404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3600407 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3600408 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3600411 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL243148 | SOPHORAFLAVANONE G | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL453642 | LEACHIANONE A | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL3600413 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3600410 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3600409 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL3600405 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL425926 | CUDRAXANTHONE D | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL3600406 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL519277 | KUSHENOL P | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL3600415 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL3600412 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL460647 | SOPHORAFLAVANONE B | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL243796 | KURARINONE | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL3600403 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL556429 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3600402 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL491534 | ISOBAVACHIN | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL3600414 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL480462 | PALLIDOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL454878 | TRIFOLIRHIZIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL3600404 | — | IC50 | > | 50000.0 | nM | - |