Assay Detail
Functional
CHEMBL3603292
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 5.02 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3601669 | — | — | 1 | 7.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.05 |
| CHEMBL3600613 | — | — | 1 | 6.30 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 6.16 |
| CHEMBL3601816 | — | — | 1 | 6.00 |
| CHEMBL3600612 | — | — | 1 | 5.92 |
| CHEMBL3601678 | — | — | 1 | 5.85 |
| CHEMBL3600607 | — | — | 1 | 5.72 |
| CHEMBL3601807 | — | — | 1 | 5.68 |
| CHEMBL3601670 | — | — | 1 | 5.66 |
| CHEMBL3601822 | — | — | 1 | 5.64 |
| CHEMBL3601829 | — | — | 1 | 5.64 |
| CHEMBL3601668 | — | — | 1 | 5.64 |
| CHEMBL3600924 | — | — | 1 | 5.57 |
| CHEMBL3600625 | — | — | 1 | 5.57 |
| CHEMBL473368 | — | — | 1 | 5.51 |
| CHEMBL3600621 | — | — | 1 | 5.42 |
| CHEMBL3601525 | — | — | 1 | 5.32 |
| CHEMBL3600617 | — | — | 1 | 5.29 |
| CHEMBL3601666 | — | — | 1 | 5.28 |
| CHEMBL3601828 | — | — | 1 | 5.28 |
| CHEMBL3601817 | — | — | 1 | 5.27 |
| CHEMBL3600619 | — | — | 1 | 5.25 |
| CHEMBL3601825 | — | — | 1 | 5.24 |
| CHEMBL3601677 | — | — | 1 | 5.24 |
| CHEMBL3600618 | — | — | 1 | 5.20 |
| CHEMBL3600624 | — | — | 1 | 5.19 |
| CHEMBL3601675 | — | — | 1 | 5.17 |
| CHEMBL3601803 | — | — | 1 | 5.17 |
| CHEMBL3600615 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3601669 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3600613 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3601816 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3600612 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3601678 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3600607 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3601807 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3601670 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3601822 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3601829 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3601668 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3600625 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3600924 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL473368 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3600621 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3601525 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3600617 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3601666 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3601828 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3601817 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3600619 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3601825 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3601677 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3600618 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3600624 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3601675 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3601803 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3600615 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3601809 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3601824 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3600611 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL3601679 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3601523 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3601660 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3601827 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL3600609 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL481 | IRINOTECAN | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL3600923 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3601673 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL3601522 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL3601814 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL3601804 | — | IC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL3601815 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL3601672 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3601676 | — | IC50 | = | 25600.0 | nM | 4.59 |
| CHEMBL3600623 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3601663 | — | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL3601805 | — | IC50 | = | 31000.0 | nM | 4.51 |