Assay Detail
Binding
CHEMBL3606141
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Inhibition of equine serum BChE pre-incubated for 5 mins before butyrylthiocholineiodide substrate addition by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.61 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130880 | IPIDACRINE | 2.0 | 1 | 7.16 |
| CHEMBL3605836 | — | — | 1 | 6.96 |
| CHEMBL3605838 | — | — | 1 | 6.48 |
| CHEMBL1531257 | — | — | 1 | 6.34 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.09 |
| CHEMBL283841 | — | — | 1 | 5.65 |
| CHEMBL1616296 | — | — | 1 | 5.05 |
| CHEMBL1617348 | — | — | 1 | 4.80 |
| CHEMBL226970 | — | — | 1 | 4.51 |
| CHEMBL1478435 | — | — | 1 | 4.44 |
| CHEMBL3605837 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130880 | IPIDACRINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3605836 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3605838 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1531257 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL95 | TACRINE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL283841 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL1616296 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL1617348 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL226970 | — | IC50 | = | 30680.0 | nM | 4.51 |
| CHEMBL1478435 | — | IC50 | = | 36150.0 | nM | 4.44 |
| CHEMBL3605837 | — | IC50 | = | 60910.0 | nM | 4.21 |