Assay Detail
Functional
CHEMBL3607329
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Cytotoxicity against human DU145 cells after 5 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.94 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.60 |
| CHEMBL2171637 | — | — | 1 | 7.10 |
| CHEMBL2171638 | — | — | 1 | 5.68 |
| CHEMBL3605304 | — | — | 1 | 5.55 |
| CHEMBL3605306 | — | — | 1 | 5.54 |
| CHEMBL3605301 | — | — | 1 | 5.50 |
| CHEMBL3605302 | — | — | 1 | 5.50 |
| CHEMBL3605305 | — | — | 1 | 5.50 |
| CHEMBL3605307 | — | — | 1 | 5.45 |
| CHEMBL3605303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2171637 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2171638 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3605304 | — | IC50 | = | 2796.0 | nM | 5.55 |
| CHEMBL3605306 | — | IC50 | = | 2898.0 | nM | 5.54 |
| CHEMBL3605301 | — | IC50 | = | 3189.0 | nM | 5.50 |
| CHEMBL3605302 | — | IC50 | = | 3148.0 | nM | 5.50 |
| CHEMBL3605305 | — | IC50 | = | 3197.0 | nM | 5.50 |
| CHEMBL3605307 | — | IC50 | = | 3575.0 | nM | 5.45 |
| CHEMBL3605303 | — | IC50 | > | 10000.0 | nM | - |