Assay Detail
Functional
CHEMBL3607332
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Cytotoxicity against human DU145 cells after 7 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.03 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50588 | EMETINE | 4.0 | 1 | 7.62 |
| CHEMBL2171637 | — | — | 1 | 7.10 |
| CHEMBL3605304 | — | — | 1 | 5.79 |
| CHEMBL2171638 | — | — | 1 | 5.70 |
| CHEMBL3605302 | — | — | 1 | 5.65 |
| CHEMBL3605301 | — | — | 1 | 5.64 |
| CHEMBL3605305 | — | — | 1 | 5.61 |
| CHEMBL3605306 | — | — | 1 | 5.61 |
| CHEMBL3605307 | — | — | 1 | 5.52 |
| CHEMBL3605303 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50588 | EMETINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2171637 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3605304 | — | IC50 | = | 1603.0 | nM | 5.79 |
| CHEMBL2171638 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL3605302 | — | IC50 | = | 2253.0 | nM | 5.65 |
| CHEMBL3605301 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3605305 | — | IC50 | = | 2449.0 | nM | 5.61 |
| CHEMBL3605306 | — | IC50 | = | 2467.0 | nM | 5.61 |
| CHEMBL3605307 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL3605303 | — | IC50 | > | 10000.0 | nM | - |