Assay Detail
Binding
CHEMBL3607546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.75 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43048 | MIDOMAFETAMINE | 3.0 | 1 | 7.21 |
| CHEMBL3603955 | — | — | 1 | 7.04 |
| CHEMBL3603954 | — | — | 1 | 6.93 |
| CHEMBL3604010 | METHYLONE | 2.0 | 1 | 6.62 |
| CHEMBL3604009 | — | — | 1 | 6.46 |
| CHEMBL3603956 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43048 | MIDOMAFETAMINE | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3603955 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3603954 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3604010 | METHYLONE | EC50 | = | 242.0 | nM | 6.62 |
| CHEMBL3604009 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL3603956 | — | EC50 | = | 573.0 | nM | 6.24 |