Assay Detail
Binding
CHEMBL3608118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BChE in equine serum using butyrylthiocholine iodide substrate by Ellman assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.51 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.36 |
| CHEMBL1198953 | — | — | 1 | 8.28 |
| CHEMBL3605357 | — | — | 1 | 8.19 |
| CHEMBL3605355 | — | — | 1 | 7.88 |
| CHEMBL3605356 | — | — | 1 | 7.88 |
| CHEMBL3605361 | — | — | 1 | 7.80 |
| CHEMBL3605354 | — | — | 1 | 7.79 |
| CHEMBL1087459 | — | — | 1 | 7.63 |
| CHEMBL3605360 | — | — | 1 | 7.50 |
| CHEMBL3605363 | — | — | 1 | 7.49 |
| CHEMBL3605367 | — | — | 1 | 7.42 |
| CHEMBL3605368 | — | — | 1 | 7.37 |
| CHEMBL3605370 | — | — | 1 | 7.36 |
| CHEMBL3605359 | — | — | 1 | 7.33 |
| CHEMBL3605362 | — | — | 1 | 7.32 |
| CHEMBL3605353 | — | — | 1 | 7.30 |
| CHEMBL3605369 | — | — | 1 | 7.28 |
| CHEMBL3605365 | — | — | 1 | 7.25 |
| CHEMBL3605366 | — | — | 1 | 7.10 |
| CHEMBL3605364 | — | — | 1 | 7.07 |
| CHEMBL3605358 | — | — | 1 | 7.03 |
| CHEMBL1098471 | — | — | 1 | 6.54 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1198953 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3605357 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3605355 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL3605356 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL3605361 | — | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL3605354 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL1087459 | — | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL3605360 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL3605363 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL3605367 | — | IC50 | = | 37.9 | nM | 7.42 |
| CHEMBL3605368 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL3605370 | — | IC50 | = | 43.5 | nM | 7.36 |
| CHEMBL3605359 | — | IC50 | = | 46.9 | nM | 7.33 |
| CHEMBL3605362 | — | IC50 | = | 47.8 | nM | 7.32 |
| CHEMBL3605353 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL3605369 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL3605365 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL3605366 | — | IC50 | = | 80.1 | nM | 7.10 |
| CHEMBL3605364 | — | IC50 | = | 85.4 | nM | 7.07 |
| CHEMBL3605358 | — | IC50 | = | 93.5 | nM | 7.03 |
| CHEMBL1098471 | — | IC50 | = | 288.6 | nM | 6.54 |
| CHEMBL807 | MEMANTINE | IC50 | - | — | - | |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL972 | SELEGILINE | IC50 | - | — | - |