Assay Detail
ADMET
CHEMBL3610073
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Inhibition of CYP3A4 (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of Novel Antagonists to the Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders (Part II).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.34 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3422009 | — | — | 1 | 4.72 |
| CHEMBL3608740 | — | — | 1 | 4.51 |
| CHEMBL3422010 | — | — | 1 | 4.30 |
| CHEMBL3422018 | — | — | 1 | 4.10 |
| CHEMBL3608680 | FEZOLINETANT | 4.0 | 1 | 4.05 |
| CHEMBL3608688 | — | — | 1 | - |
| CHEMBL3608687 | — | — | 1 | - |
| CHEMBL3608686 | — | — | 1 | - |
| CHEMBL3608685 | — | — | 1 | - |
| CHEMBL3608684 | — | — | 1 | - |
| CHEMBL3608683 | — | — | 1 | - |
| CHEMBL3608682 | — | — | 1 | - |
| CHEMBL3608681 | — | — | 1 | - |
| CHEMBL3608741 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3422009 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3608740 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3422010 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3422018 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL3608680 | FEZOLINETANT | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL3608688 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608686 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608685 | — | IC50 | - | — | - | |
| CHEMBL3608684 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3608681 | — | IC50 | - | — | - | |
| CHEMBL3608741 | — | IC50 | > | 100000.0 | nM | - |