Assay Detail
ADMET
CHEMBL3611298
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Cytotoxicity against MDCK cells assessed as cell viability after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Canis lupus familiaris |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid compounds with two redox centres: modular synthesis of chalcogen-containing lapachones and studies on their antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.52 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.37 |
| CHEMBL3609556 | — | — | 1 | 5.97 |
| CHEMBL3609562 | — | — | 1 | 5.73 |
| CHEMBL3609552 | — | — | 1 | 5.68 |
| CHEMBL3609563 | — | — | 1 | 5.58 |
| CHEMBL3609560 | — | — | 1 | 5.56 |
| CHEMBL3609557 | — | — | 1 | 5.52 |
| CHEMBL3609554 | — | — | 1 | 5.50 |
| CHEMBL3609559 | — | — | 1 | 5.43 |
| CHEMBL3609561 | — | — | 1 | 5.42 |
| CHEMBL3609558 | — | — | 1 | 5.36 |
| CHEMBL3609555 | — | — | 1 | 5.30 |
| CHEMBL3609553 | — | — | 1 | 5.02 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3609556 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL3609562 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL3609552 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL3609563 | — | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL3609560 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL3609557 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3609554 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3609559 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL3609561 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL3609558 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL3609555 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL3609553 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 13500.0 | nM | 4.87 |