Assay Detail
Functional
CHEMBL3619928
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Antiproliferative activity against human A2780 cells in lipid reduced medium in absence of palmitate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fatty Acid Synthase (FASN) Inhibitors as Potential Treatment for Cancer, Obesity, and Liver Related Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.78 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3617746 | — | — | 1 | 8.27 |
| CHEMBL3617741 | — | — | 1 | 7.13 |
| CHEMBL3617742 | — | — | 1 | 7.12 |
| CHEMBL3617743 | — | — | 1 | 6.33 |
| CHEMBL3617745 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3617746 | — | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL3617741 | — | IC50 | = | 74.13 | nM | 7.13 |
| CHEMBL3617742 | — | IC50 | = | 75.86 | nM | 7.12 |
| CHEMBL3617743 | — | IC50 | = | 467.74 | nM | 6.33 |
| CHEMBL3617745 | — | IC50 | = | 9332.54 | nM | 5.03 |