Assay Detail
Functional
CHEMBL3620828
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Cytotoxicity against human THP1 cells assessed as reduction in cell viability
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.00 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3260857 | — | — | 1 | 5.66 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.22 |
| CHEMBL3260858 | — | — | 1 | 5.19 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.75 |
| CHEMBL3617543 | — | — | 1 | 4.60 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3260857 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3260858 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3617543 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL941 | IMATINIB | IC50 | = | 25000.0 | nM | 4.60 |