Assay Detail
ADMET
CHEMBL3624432
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Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.64 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2441127 | — | — | 1 | 6.57 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.43 |
| CHEMBL2441128 | — | — | 1 | 6.00 |
| CHEMBL2441129 | — | — | 1 | 5.96 |
| CHEMBL3621996 | — | — | 1 | 5.88 |
| CHEMBL3621992 | — | — | 1 | 5.66 |
| CHEMBL3621997 | — | — | 1 | 5.64 |
| CHEMBL3621993 | — | — | 1 | 5.19 |
| CHEMBL3621994 | — | — | 1 | 5.10 |
| CHEMBL3621989 | — | — | 1 | 4.86 |
| CHEMBL463017 | — | — | 1 | 4.70 |
| CHEMBL3622003 | — | — | 1 | - |
| CHEMBL3622004 | — | — | 1 | - |
| CHEMBL3622005 | — | — | 1 | - |
| CHEMBL3622295 | — | — | 1 | - |
| CHEMBL3622296 | — | — | 1 | - |
| CHEMBL3622297 | — | — | 1 | - |
| CHEMBL3621995 | — | — | 1 | - |
| CHEMBL3622299 | — | — | 1 | - |
| CHEMBL1999309 | — | — | 1 | - |
| CHEMBL3622300 | — | — | 1 | - |
| CHEMBL3622301 | — | — | 1 | - |
| CHEMBL3622302 | — | — | 1 | - |
| CHEMBL469166 | — | — | 1 | - |
| CHEMBL3621990 | — | — | 1 | - |
| CHEMBL2282148 | — | — | 1 | - |
| CHEMBL394882 | NOR-BETA-LAPACHONE | — | 1 | - |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | - |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | - |
| CHEMBL3622298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2441127 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2441128 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2441129 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3621996 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL3621992 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3621997 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL3621993 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL3621994 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3621989 | — | IC50 | = | 13830.0 | nM | 4.86 |
| CHEMBL463017 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3622297 | — | IC50 | > | 15050.0 | nM | - |
| CHEMBL3622296 | — | IC50 | > | 15380.0 | nM | - |
| CHEMBL3622295 | — | IC50 | > | 14660.0 | nM | - |
| CHEMBL3622005 | — | IC50 | > | 13150.0 | nM | - |
| CHEMBL3622004 | — | IC50 | > | 13540.0 | nM | - |
| CHEMBL3622003 | — | IC50 | > | 12100.0 | nM | - |
| CHEMBL3622002 | — | IC50 | > | 14320.0 | nM | - |
| CHEMBL3622001 | — | IC50 | > | 13540.0 | nM | - |
| CHEMBL3622000 | — | IC50 | > | 12650.0 | nM | - |
| CHEMBL3621999 | — | IC50 | > | 12980.0 | nM | - |
| CHEMBL3621998 | — | IC50 | > | 14920.0 | nM | - |
| CHEMBL3621991 | — | IC50 | > | 18850.0 | nM | - |
| CHEMBL3621995 | — | IC50 | > | 9500.0 | nM | - |
| CHEMBL3622299 | — | IC50 | > | 12190.0 | nM | - |
| CHEMBL1999309 | — | IC50 | > | 15050.0 | nM | - |
| CHEMBL3622300 | — | IC50 | > | 15710.0 | nM | - |
| CHEMBL3622301 | — | IC50 | > | 15710.0 | nM | - |
| CHEMBL3622302 | — | IC50 | > | 14960.0 | nM | - |
| CHEMBL469166 | — | IC50 | > | 19750.0 | nM | - |
| CHEMBL3621990 | — | IC50 | > | 16710.0 | nM | - |
| CHEMBL2282148 | — | IC50 | > | 21080.0 | nM | - |
| CHEMBL394882 | NOR-BETA-LAPACHONE | IC50 | > | 21900.0 | nM | - |
| CHEMBL15192 | LAPACHONE | IC50 | > | 20600.0 | nM | - |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | > | 20660.0 | nM | - |
| CHEMBL3622298 | — | IC50 | > | 10910.0 | nM | - |