Assay Detail
Functional
CHEMBL3624975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human DU145 cells after 72 hrs by MTT assay
41
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 5.11 | 5.76 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3621815 | — | — | 1 | 5.76 |
| CHEMBL3621825 | — | — | 1 | 5.60 |
| CHEMBL3622212 | — | — | 1 | 5.59 |
| CHEMBL3622217 | — | — | 1 | 5.44 |
| CHEMBL3622213 | — | — | 2 | 5.34 |
| CHEMBL3622215 | — | — | 1 | 5.20 |
| CHEMBL3622214 | — | — | 1 | 5.20 |
| CHEMBL3621762 | — | — | 1 | 5.17 |
| CHEMBL594366 | — | — | 1 | 5.13 |
| CHEMBL3621764 | — | — | 1 | 5.12 |
| CHEMBL3622216 | — | — | 1 | 5.12 |
| CHEMBL3621830 | — | — | 1 | 5.10 |
| CHEMBL3621826 | — | — | 1 | 5.08 |
| CHEMBL3621837 | — | — | 1 | 5.08 |
| CHEMBL3621832 | — | — | 1 | 5.04 |
| CHEMBL3621766 | — | — | 1 | 5.02 |
| CHEMBL3622218 | — | — | 1 | 5.01 |
| CHEMBL3621816 | — | — | 1 | 4.97 |
| CHEMBL3621817 | — | — | 1 | 4.95 |
| CHEMBL3621827 | — | — | 1 | 4.92 |
| CHEMBL3621767 | — | — | 1 | 4.90 |
| CHEMBL3621835 | — | — | 1 | 4.89 |
| CHEMBL3621819 | — | — | 1 | 4.88 |
| CHEMBL3621824 | — | — | 1 | 4.86 |
| CHEMBL3621831 | — | — | 1 | 4.85 |
| CHEMBL3621823 | — | — | 1 | 4.84 |
| CHEMBL3621828 | — | — | 1 | 4.80 |
| CHEMBL3621763 | — | — | 1 | - |
| CHEMBL3621765 | — | — | 1 | - |
| CHEMBL3621833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3621815 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL3621825 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL3622212 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL3622217 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL3622213 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL3622215 | — | IC50 | = | 6380.0 | nM | 5.20 |
| CHEMBL3622214 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL3621762 | — | IC50 | = | 6680.0 | nM | 5.17 |
| CHEMBL594366 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL3621764 | — | IC50 | = | 7640.0 | nM | 5.12 |
| CHEMBL3622216 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL3621830 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL3621826 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL3621837 | — | IC50 | = | 8260.0 | nM | 5.08 |
| CHEMBL3621832 | — | IC50 | = | 9120.0 | nM | 5.04 |
| CHEMBL3621766 | — | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL3622218 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL3621816 | — | IC50 | = | 10680.0 | nM | 4.97 |
| CHEMBL3621817 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL3621827 | — | IC50 | = | 11970.0 | nM | 4.92 |
| CHEMBL3621767 | — | IC50 | = | 12680.0 | nM | 4.90 |
| CHEMBL3621835 | — | IC50 | = | 12910.0 | nM | 4.89 |
| CHEMBL3621819 | — | IC50 | = | 13280.0 | nM | 4.88 |
| CHEMBL3621824 | — | IC50 | = | 13850.0 | nM | 4.86 |
| CHEMBL3621831 | — | IC50 | = | 14090.0 | nM | 4.85 |
| CHEMBL3621823 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL3621828 | — | IC50 | = | 15890.0 | nM | 4.80 |
| CHEMBL3621822 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621212 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621820 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3622213 | — | Activity | - | — | - | |
| CHEMBL3621829 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621821 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621834 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621836 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621818 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621838 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3622211 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621763 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621833 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3621765 | — | IC50 | > | 15000.0 | nM | - |