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Assay Detail

CHEMBL3625311

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Functional
Cytotoxicity against human U87 cells assessed as growth inhibition after 72 hrs by SRB assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type U-87MG ATCC
Confidence 1 — Organism
Curated By Autocuration

Publication

Discovery of mitochondria-targeting berberine derivatives as the inhibitors of proliferation, invasion and migration against rat C6 and human U87 glioma cells
Fu S, Xie Y, Tuo J, Wang Y, Zhu W, Wu S, Yan G, Hu H
Medchemcomm (2015) 6 : 164 -173
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.71 4.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL810 TEMOZOLOMIDE 4.0 1 4.71
CHEMBL481 IRINOTECAN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL810 TEMOZOLOMIDE IC50 = 19380.0 nM 4.71
CHEMBL481 IRINOTECAN IC50 > 250000.0 nM -