Assay Detail
Binding
CHEMBL3630375
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-DAMGO from mu opioid receptor (unknown origin) transfected in HEK293 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.04 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3627737 | — | — | 1 | 9.29 |
| CHEMBL3629337 | — | — | 1 | 9.25 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 8.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3627737 | — | Ki | = | 0.515 | nM | 9.29 |
| CHEMBL3629337 | — | Ki | = | 0.565 | nM | 9.25 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 2.6 | nM | 8.59 |