Assay Detail
Functional
CHEMBL3630378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor (unknown origin) transfected in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of new endomorphin analogs with enhanced central antinociception after peripheral administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 9.41 | 10.20 |
| Emax | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3629337 | — | — | 2 | 10.20 |
| CHEMBL3627737 | — | — | 2 | 10.19 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 2 | 7.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3629337 | — | EC50 | = | 0.0629 | nM | 10.20 |
| CHEMBL3627737 | — | EC50 | = | 0.0643 | nM | 10.19 |
| CHEMBL316446 | ENDOMORPHIN-1 | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL316446 | ENDOMORPHIN-1 | Emax | = | 83.13 | % | - |
| CHEMBL3629337 | — | Emax | = | 98.22 | % | - |
| CHEMBL3627737 | — | Emax | = | 97.01 | % | - |