Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3631055

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human EGFR after 1 hr using [gamma-32P]ATP
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Epidermal growth factor receptor (CHEMBL203)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of di-aryl urea derivatives as c-Kit inhibitors.
Ravez S, Arsenlis S, Barczyk A, Dupont A, Frédérick R, Hesse S, Kirsch G, Depreux P, Goossens L.
Bioorg Med Chem (2015) 23 : 7340 -7347
PubMed 26526740 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.95 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1688539 1 7.52
CHEMBL301018 1 6.40
CHEMBL3628800 1 6.23
CHEMBL2018756 1 6.05
CHEMBL3628907 1 5.90
CHEMBL3628792 1 5.88
CHEMBL3628791 1 5.53
CHEMBL3628906 1 5.48
CHEMBL3628799 1 5.40
CHEMBL3628796 1 5.11
CHEMBL3628793 1 -
CHEMBL3628794 1 -
CHEMBL3628795 1 -
CHEMBL3628797 1 -
CHEMBL3628798 1 -
CHEMBL1278148 1 -
CHEMBL3628801 1 -
CHEMBL3628802 1 -
CHEMBL3628803 1 -
CHEMBL3628811 1 -
CHEMBL3628804 1 -
CHEMBL3628805 1 -
CHEMBL3628810 1 -
CHEMBL3628809 1 -
CHEMBL3628808 1 -
CHEMBL2018882 1 -
CHEMBL3628807 1 -
CHEMBL3628806 1 -
CHEMBL2018884 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1688539 IC50 = 30.0 nM 7.52
CHEMBL301018 IC50 = 400.0 nM 6.40
CHEMBL3628800 IC50 = 590.0 nM 6.23
CHEMBL2018756 IC50 = 900.0 nM 6.05
CHEMBL3628907 IC50 = 1260.0 nM 5.90
CHEMBL3628792 IC50 = 1330.0 nM 5.88
CHEMBL3628791 IC50 = 2980.0 nM 5.53
CHEMBL3628906 IC50 = 3290.0 nM 5.48
CHEMBL3628799 IC50 = 3950.0 nM 5.40
CHEMBL3628796 IC50 = 7710.0 nM 5.11
CHEMBL3628793 IC50 > 10000.0 nM -
CHEMBL3628794 IC50 > 10000.0 nM -
CHEMBL3628795 IC50 > 10000.0 nM -
CHEMBL3628797 IC50 > 10000.0 nM -
CHEMBL3628798 IC50 > 10000.0 nM -
CHEMBL1278148 IC50 > 10000.0 nM -
CHEMBL3628801 IC50 > 10000.0 nM -
CHEMBL3628802 IC50 > 10000.0 nM -
CHEMBL3628803 IC50 > 10000.0 nM -
CHEMBL3628811 IC50 > 10000.0 nM -
CHEMBL3628804 IC50 > 10000.0 nM -
CHEMBL3628805 IC50 > 10000.0 nM -
CHEMBL3628810 IC50 > 10000.0 nM -
CHEMBL3628809 IC50 > 10000.0 nM -
CHEMBL3628808 IC50 > 10000.0 nM -
CHEMBL2018882 IC50 > 10000.0 nM -
CHEMBL3628807 IC50 > 10000.0 nM -
CHEMBL3628806 IC50 > 10000.0 nM -
CHEMBL2018884 IC50 > 10000.0 nM -