Compound Detail
CHEMBL3628907
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Basic Information
| ChEMBL ID | CHEMBL3628907 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WLKMXZAOYIRUBM-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
529.9
MW (Da)
7.42
ALogP
5
HBA
2
HBD
76.1
PSA (Ų)
0.29
QED
2
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.9 | 5.9 | 1260.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 15.0 | nM | 7.82 | Inhibition of human recombinant VEGFR-2 after 1 hr using [gamma-32P]ATP | 26526740 |
| Epidermal growth factor receptor | IC50 | = | 1260.0 | nM | 5.9 | Inhibition of human EGFR after 1 hr using [gamma-32P]ATP | 26526740 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26526740 | 10.1016/j.bmc.2015.10.035 | Vascular endothelial growth factor receptor 2 | 1 |
| 26526740 | 10.1016/j.bmc.2015.10.035 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine