Assay Detail
Functional
CHEMBL3632268
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human IGROV1 cells after 96 hrs by CellTiter-Blue assay in presence of 200 nM folic acid
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | IGROV-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.73 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834488 | — | — | 1 | 6.90 |
| CHEMBL3628346 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834488 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3628346 | — | IC50 | = | 276.0 | nM | 6.56 |