Assay Detail

CHEMBL3635480

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ADMET

Competitive inhibition of CYP2D6 (unknown origin) using dextromethorphan substrate

ChEMBL ↗

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Target

Cytochrome P450 2D6 (CHEMBL289) ↗

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Cytochrome P450 2D6 (CHEMBL289) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cytochrome P450 2D6

CHEMBL289

Anchored from Assay target.

Protein identity Cytochrome P450 2D6

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Cytochrome P450 2D6 (CHEMBL289) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Development of Safe and Effective Botanical Dietary Supplements.

van Breemen RB.
J Med Chem (2015) 58 : 8360 -8372
PubMed 26125082 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.01	7.11

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL486179	PROTOPINE	—	1	7.11
CHEMBL520043	ALLOCRYPTOPINE	—	1	6.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL486179	PROTOPINE	Ki	=	78.0	nM	7.11
CHEMBL520043	ALLOCRYPTOPINE	Ki	=	122.0	nM	6.91