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Assay Detail

CHEMBL3637075

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative effects against human SHEP cells after 72 hrs by Alamar blue assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SHEP
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity.
Chen Y, Cass SL, Kutty SK, Yee EM, Chan DS, Gardner CR, Vittorio O, Pasquier E, Black DS, Kumar N.
Bioorg Med Chem Lett (2015) 25 : 5377 -5383
PubMed 26432036 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.13 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3633910 1 6.16
CHEMBL3633750 1 5.85
CHEMBL3633747 1 5.75
CHEMBL3633745 1 5.55
CHEMBL3633914 1 5.47
CHEMBL3633755 1 5.43
CHEMBL3633753 1 5.41
CHEMBL3633746 1 5.40
CHEMBL3633912 1 5.38
CHEMBL3633909 1 5.31
CHEMBL3633749 1 5.29
CHEMBL3633742 1 5.24
CHEMBL3633743 1 5.24
CHEMBL3633756 1 5.24
CHEMBL3633752 1 5.18
CHEMBL195560 ISOPHENOXODIOL 3.0 1 5.08
CHEMBL3633754 1 5.04
CHEMBL3633751 1 4.91
CHEMBL3633744 1 4.82
CHEMBL3633911 1 4.70
CHEMBL3633908 1 4.61
CHEMBL3633748 1 4.56
CHEMBL3633913 1 4.45
CHEMBL3633917 1 4.16
CHEMBL3633915 1 4.06
CHEMBL3633916 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3633910 IC50 = 700.0 nM 6.16
CHEMBL3633750 IC50 = 1400.0 nM 5.85
CHEMBL3633747 IC50 = 1800.0 nM 5.75
CHEMBL3633745 IC50 = 2800.0 nM 5.55
CHEMBL3633914 IC50 = 3400.0 nM 5.47
CHEMBL3633755 IC50 = 3700.0 nM 5.43
CHEMBL3633753 IC50 = 3900.0 nM 5.41
CHEMBL3633746 IC50 = 4000.0 nM 5.40
CHEMBL3633912 IC50 = 4200.0 nM 5.38
CHEMBL3633909 IC50 = 4900.0 nM 5.31
CHEMBL3633749 IC50 = 5100.0 nM 5.29
CHEMBL3633742 IC50 = 5800.0 nM 5.24
CHEMBL3633743 IC50 = 5700.0 nM 5.24
CHEMBL3633756 IC50 = 5700.0 nM 5.24
CHEMBL3633752 IC50 = 6600.0 nM 5.18
CHEMBL195560 ISOPHENOXODIOL IC50 = 8400.0 nM 5.08
CHEMBL3633754 IC50 = 9100.0 nM 5.04
CHEMBL3633751 IC50 = 12200.0 nM 4.91
CHEMBL3633744 IC50 = 15100.0 nM 4.82
CHEMBL3633911 IC50 = 19900.0 nM 4.70
CHEMBL3633908 IC50 = 24600.0 nM 4.61
CHEMBL3633748 IC50 = 27500.0 nM 4.56
CHEMBL3633913 IC50 = 35700.0 nM 4.45
CHEMBL3633917 IC50 = 69000.0 nM 4.16
CHEMBL3633915 IC50 = 86800.0 nM 4.06
CHEMBL3633916 IC50 = 171000.0 nM -